Mónica Zufiría

The paper shows that energy scarcity and mitochondrial translation impairment cause ALS-FTD-related proteins to form perinuclear stress granule clusters, potentially leading to pathological inclusions.

This study shows that GRN haploinsufficiency in FTD causes lysosomal and mitochondrial dysfunction, lipid metabolism changes, and autophagy impairment, which may contribute to disease pathogenesis.