Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease
Xiaoxi Yang, Kyla Masarik, Xiaochuan Sun…·Huichun Zhan
This study shows that JAK2V617F-mutant hematopoiesis causes cardiac microvascular disease, and blocking MPL signaling in endocardial endothelial cells improves cardiac function.