Author
University of PittsburghORCID 0000-0002-2686-3387Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Amal Taher Elhaw, Priscilla W. Tang, Ya-Yun Cheng…·Nadine Hempel
This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.
Mary C. Rominger, Siobhan O’Brien, Saksham Gupta…·Alice H. Berger
This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.
Ya-Yun Cheng, Beth L. Worley, Zaineb Javed…·Nadine Hempel
This study shows that loss of MPZL3 promotes EMT and chemoresistance in ovarian cancer by reducing adhesion and increasing drug resistance.
Caroline A. Chang, Ya-Yun Cheng, Shriya Kamlapurkar…·Nadine Hempel
This study shows GPX3 is necessary for ovarian cancer growth in vivo and promotes GDF15 expression, linking it to immune checkpoint inhibitor response.
Phoebe C. R. Parrish, James D. Thomas, Austin M. Gabel…·Alice H. Berger
The paper identifies synthetic lethal and tumor suppressive paralog pairs in the human genome using a CRISPR-based approach, revealing new drug targets and essential gene families.