Sangwoo Park

This study engineers CAR-T cells to secrete KLK5, a protease that remodels the mucin-rich glycocalyx, enhancing CAR-T cell function and tumor control in xenograft models.

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

This paper identifies glycocalyx thickness as a targetable physical phenotype and demonstrates that castanospermine reduces it, enhancing CAR-T cell efficacy against gastric cancer.

The paper shows that dimerization activates the Inversin complex in C. elegans, with optogenetic stimulation and genetic studies supporting this mechanism.

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.