Xiao Xu

This study shows that selenoprotein P deficiency promotes hepatocellular carcinoma by inducing neutrophil senescence and an immunosuppressive microenvironment.

This study constructs a technical platform to investigate cell cycle- and autophagy-related nanoparticle accumulation, revealing distinct accumulation patterns in specific cell cycle phases.

miRTalk infers EV-derived miRNA-mediated cell-cell communication from scRNA-seq data, showing high accuracy in simulated and real datasets.

The paper identifies cholesterol binding to VCAM-1 as a mechanism promoting vascular inflammation by stabilizing VCAM-1 and enhancing immune cell recruitment.

SpaTalk infers cell-cell communication from spatial transcriptomic data using a knowledge graph and graph network, outperforming existing methods on public datasets and revealing insights into tissue communication mechanisms.

The paper constructs a single-cell transcriptomic atlas of transplanted livers and identifies an EAD-associated pathogenic cellular module.