Edward J. Banigan

This study shows lamin B1 affects nuclear shape and integrity via chromatin stiffness, not lamin stiffness, using mechanical measurements and simulations.

This study shows PDS5 proteins regulate genome architecture by stopping loop extrusion and strengthening CTCF boundaries through NIPBL dissociation from cohesin.

The paper discovers a novel chromatin folding structure, compartment S, in the silkworm Bombyx mori using Hi-C, showing unique loop extrusion and contact patterns.

The paper models nuclear chromatin compartmentalization using crosslinking, contractile motors, and deformable lamina, showing how these factors drive genomic segregation and heterochromatin formation.

The paper uses Region Capture Micro-C to study microcompartment formation during mitosis-to-G1 transition, finding they form in prometaphase and are influenced by chromatin compaction and loop extrusion.

The paper investigates how peripheral heterochromatin tethering influences nuclear mechanical response through simulations and experiments.

This study uses a polymer model to show that chromatin phase separation and nuclear shape fluctuations are correlated, with heterochromatin levels and interactions affecting nuclear stability.

This study shows that CTCF orientation and R-loops regulate cohesin-mediated DNA looping and 3D genome structure.

The paper shows that transcribing RNA polymerases act as moving barriers to cohesin, altering chromatin organization near active genes.