Yuen Gao

The paper calculates ribosome protein stoichiometry ratios across tissues and developmental stages, revealing functional ribosome heterogeneity in health and disease.

This study shows that deleting the autism risk gene Ash1l in mice leads to neural hyperactivity and related behavioral and cognitive deficits.

This study shows that KDM2B dysfunction leads to neural stem cell senescence and ASD/ID-like behaviors in mice, linking 12q24.31 microdeletions to neurodevelopmental disorders.

This study shows that loss of ASH1L in developing mouse brains leads to autistic-like behaviors and cognitive impairments, establishing a causal link between ASH1L mutations and ASD/ID.

This study shows FGF/ERK signaling regulates PRC2 occupancy in mESCs via JARID2 and reveals transcription factors drive bivalent gene de-repression independently of PRC2 occupancy.