Yue Hu

This study identifies RNA binding domains in HNRNPR, showing that RRM3 and a C-terminal charged region are critical for RNA binding, and reveals specific interactions with G-quadruplexes.

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

The paper investigates how RNA-protein binding site context, not just valence, affects biomolecular condensate properties in Ashbya gossypii.

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

The paper introduces LAMAR, a transformer-based foundation language model for RNA regulation, which outperforms state-of-the-art methods in predicting mRNA translation efficiency and half-life.

The paper examines interspecies differences in RNA-protein interactions using the neuronal RNA binding protein UNK, finding conserved binding patterns and species-specific sequence determinants.

The paper systematically identifies PRMT interactomes and shows arginine methylation regulates RNA splicing and translation by affecting ribosome assembly and cell growth.