Yuguang J. Ban

This study shows miR-29a reprograms exhausted CD8 T cells into a stem-like state, enhancing their effector function and response to checkpoint inhibitors.

This study shows that targeting CREB reduces immunosuppression in pancreatic cancer by altering macrophage polarization and enhancing immunotherapy effectiveness.

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

pathwayPCA is an R package that performs integrative pathway analysis with modern PCA methods and gene selection, enabling multi-omics data analysis and sample-specific pathway activity estimation.

The paper creates a gene set database for pathway analysis in mouse, enabling pathway analysis and meta-analysis of gene expression signatures.