John S. Condeelis

This study identifies macrophage Tie2 signaling as critical for TMEM doorway-mediated vascular permeability and metastatic dissemination in breast cancer.

This study identifies MenaINV as essential for breast cancer stem cell extravasation but not survival, revealing distinct pathways for metastatic dominance.

This study shows that Mena promotes KRAS-driven pancreatic tumor growth and metastasis by enhancing oncogenic signaling pathways.

This study identifies TMEM doorways as a mechanism for metastasis in PDAC, showing Tie2 macrophages facilitate intravasation and that targeting Tie2 improves survival in mouse models.

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

This study shows paclitaxel induces MenaINV in breast cancer cells by repolarizing tumor-associated macrophages, enhancing metastasis.

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.

This study shows that PYK2 and FAK regulate breast cancer metastasis through distinct mechanisms, with PYK2 affecting motility and FAK reducing tumor size and metastasis.