Author

Iromi Wanigasuriya

The University of MelbourneORCID 0000-0002-2941-8764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Andrew KeniryiD· 3 shared Kelsey A. BresliniD· 3 shared Marnie E. BlewittiD· 3 shared Matthew E. RitchieiD· 3 shared Quentin A. GouiliD· 3 shared Tamara J BeckiD· 3 shared Andrés Tapia del FierroiD· 2 shared Ellise A RoperiD· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Andrew KeniryORCID

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3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedSep 25, 2023

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease

Andrés Tapia del Fierro, Bianca den Hamer, Natalia Benetti…·Marnie E. Blewitt

This study identifies a mutation in SMCHD1 that enhances gene silencing and disrupts developmental processes, revealing distinct roles of SMCHD1 in chromatin structure and gene regulation.

26 citations

mouseChIP-seq

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GenomicsEpigenetics & ChromatinPeer-reviewedJul 17, 2022

Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation

Iromi Wanigasuriya, Sarah Kinkel, Tamara J Beck…·Quentin A. Gouil

This study shows maternal SMCHD1 is essential for imprinted Xist expression and X chromosome inactivation in mouse embryos and placenta.

6 citations

mouseDNA methylation

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GenomicseLifePeer-reviewedNov 13, 2020

Smchd1 is a maternal effect gene required for autosomal imprinting

Iromi Wanigasuriya, Quentin A. Gouil, Sarah Kinkel…·Marnie E. Blewitt

This study identifies Smchd1 as a maternal effect gene that regulates imprinted expression of 16 genes by translating polycomb-mediated histone methylation marks into a heritable chromatin state.

39 citations

mouseexperimental assay

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