Jake M. Cashion

This study shows that pericyte ablation in adult mice leads to blood-brain barrier leakage, gliosis, and behavioral changes such as reduced movement and impaired balance.

This study compares iPSC-derived pericytes to primary human brain vascular pericytes, showing they express pericyte markers and respond to growth factors and vasoactive mediators, though with gene expression differences.

The paper identifies a subpopulation of microglia associated with pericytes in the brain and shows this population is reduced in Alzheimer's disease in the superior frontal gyrus.

This study maps H3K4me3 and H3K27ac in mouse neurons across lifespan, revealing epigenetic changes associated with neuronal aging and identifying new aging-related features.