Cell BiologybioRxivPreprint
A chemogenetic CRISPR knockout screen identifies a ubiquitin-mediated calcineurin-BMP pathway relay in T cell activation
DOI 10.64898/2026.07.08.737199
Author
University of CopenhagenORCID 0000-0002-3111-0769Unclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Bob Meeusen, Sara M. Ambjørn, Jiri Veis…·Jakob Nilsson
The paper identifies CYB5R4 as an evolutionarily conserved reductase that activates PP4 and PP6 by reducing their catalytic metal ions, essential for cell viability under oxidative stress.