Cell BiologybioRxivPreprint
A chemogenetic CRISPR knockout screen identifies a ubiquitin-mediated calcineurin-BMP pathway relay in T cell activation
DOI 10.64898/2026.07.08.737199
Author
Jakob Nilsson
University of CopenhagenORCID 0000-0003-4100-1125Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 40 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 shared papersCell Biology
Arminja Nadine KettenbachORCID
Mutual co-authors in cluster
8 papers
Recent·Most cited
- Cell BiologyJournal of Cell SciencePeer-reviewed
FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism
Iker Benavides-Puy, Suzanne Vigneron, Arminja Nadine Kettenbach…·Jakob Nilsson
This study identifies a bipartite binding mechanism of FAM122A to PP2A-B55, revealing a conserved phosphorylation site involved in cell cycle regulation.
- Cell BiologyNature Structural & Molecular BiologyPeer-reviewed
A proteome-wide dependency map of protein interaction motifs
Sara M. Ambjørn, Bob Meeusen, Johanna Kliche…·Jakob Nilsson
The paper systematically assesses the function of short linear motifs (SLiMs) by mutating and screening them in human cells, identifying essential SLiMs for cell proliferation and uncovering novel classes and binding partners.
8 citationstop 1% - Cell BiologyCurrent BiologyPeer-reviewed
POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy
Margarida Moura, João Barbosa, Inês Mendes Pinto…·Carlos Conde
This study shows POLO kinase phosphorylates PP187B to inhibit its interaction with MPS1, maintaining SAC activity and preventing aneuploidy during mitosis.
2 citations - Cell BiologybioRxivPreprint
A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions
Bob Meeusen, Sara M. Ambjørn, Jiri Veis…·Jakob Nilsson
The paper identifies CYB5R4 as an evolutionarily conserved reductase that activates PP4 and PP6 by reducing their catalytic metal ions, essential for cell viability under oxidative stress.
- Cell BiologyScience AdvancesPeer-reviewed
Substrate recognition principles for the PP2A-B55 protein phosphatase
Thomas Kruse, Dimitriya Hristoforova Garvanska, Julia K. Varga…·Jakob Nilsson
The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.
28 citations - Molecular BiologybioRxivPreprint
Catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis
Selene Sellés‐Baiget, Sara M. Ambjørn, Alberto Carli…·Julien P. Duxin
This study identifies catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis using CRISPR screening and TLS analysis.
4 citations - Cell BiologybioRxivPreprint
The RZZ complex facilitates Mad1 binding to Bub1 ensuring efficient checkpoint signaling
Gang Zhang, Thomas Kruse, Jakob Nilsson
The paper shows the RZZ complex helps Mad1 bind to Bub1, which is essential for checkpoint signaling, and that this interaction is conserved from yeast to humans.
DOI 10.1101/322834