Ling Liang

This study identifies ADP-ribose as a mediator of neuronal ferroptosis through metabolic rewiring, showing that blocking its signaling alleviates cognitive decline in mouse models.

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

This study reveals the structural mechanism of cholesterol sensing by LYCHOS, showing how cholesterol binding modulates its interaction with GATOR1 to activate mTORC1.

The paper shows blebs regulate phosphoinositides distribution via the Septin-SH3KBP1-PI3K axis, promoting cell survival during anoikis resistance.

This study reveals how XPR1, a phosphate exporter, is regulated by KIDINS220 and inositol pyrophosphate through structural and functional analyses.

The paper identifies a conserved N-terminal motif in CUL3 that mediates dimerization and activates CRL3KLHL22 E3 ligase function.