Akata Saha

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

This study shows that in vitro-derived cDC1s resemble tumor-infiltrating DCs and that MHC-I and MHC-II antigen presentation by these cells is essential for effective cancer immunotherapy.

This study identifies BCSCs as drivers of CD8+ T cell exhaustion in breast cancer subtypes, showing NOTCH1/RBPJ/PD-L1 axis regulation and potential therapeutic targeting.

The paper constructs an integrated atlas of tumor-infiltrating dendritic cells across species and immunotherapy conditions, revealing conserved activation states and spatial reorganization in response to therapy.

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.