Author
Icahn School of Medicine at Mount SinaiORCID 0000-0002-3136-3280Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Ruoxi Wu, Harsha Venkatesh, Carisse Lansiquot…·Michael B. Lazarus
This study reveals the structural and biophysical mechanisms of YicC, a novel bacterial RNase, showing its RNA binding and cleavage mechanism involving Mg2+ ions and dimeric conformations.
Carisse Lansiquot, Ruoxi Wu, Joanna P. Davies…·Michael B. Lazarus
The paper identifies AMI-1 as an inhibitor of NMNAT1, shows its effect on NAD+ levels and cancer cell viability, and determines its binding mechanism via cryo-EM.
Ruoxi Wu, Susmita Khamrui, Tetyana Dodatko…·Sander M. Houten
The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.