Author

Joseph F. Arboleda‐Velásquez

Massachusetts Eye and Ear InfirmaryORCID 0000-0002-3192-9117Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:machine learning (classical)· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Diego Sepúlveda FallaiD· 2 shared Francisco Javier LoperaiD· 2 shared Nelson David Villalba‐Moreno· 2 shared Yakeel T. QuiroziD· 2 shared Adam R. FergusoniD· 1 shared Ana Y. BaenaiD· 1 shared Andrés VillegasiD· 1 shared Carolina Ortiz‐CorderoiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Diego Sepúlveda FallaORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 20, 2026

A lifespan single-cell atlas of the human developing hippocampus benchmarks familial Alzheimer's disease brain organoids.

Ekaterina Ivleva, Emil Kriukov, Joseph F. Arboleda‐Velásquez, Petr Y. Baranov

The paper constructs a lifespan single-cell atlas of the human developing hippocampus and benchmarks iPSC-derived brain organoids with a PSEN1 mutation linked to familial Alzheimer's disease.

DOI 10.64898/2026.09.18.752796

humanscRNA-seq

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NeurosciencebioRxivPreprintJul 22, 2026

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease

Jessica Lisa Villalba-Moreno, Yassir El‐Amri, K I Kim…·Diego Sepúlveda Falla

The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.

DOI 10.64898/2026.07.17.739026

humanmouse

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NeurosciencebioRxivPreprintMar 28, 2024

Plasma Proteomics of Genetic Brain Arteriosclerosis and Dementia Syndrome Identifies Signatures of Fibrosis, Angiogenesis, and Metabolic Alterations

Jonah N. Keller, Hannah Radabaugh, Nikolaos Karvelas…·Fanny M. Elahi

The paper identifies plasma proteomic signatures associated with CADASIL stages, revealing fibrosis, angiogenesis, and metabolic alterations.

DOI 10.1101/2024.03.28.587249

humanproteomics

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NeurosciencebioRxivPreprintJan 11, 2023

APOE3 Christchurch modulates tau phosphorylation and regulates β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer's cases

Randall C. Mazzarino, Paula Andrea Perez-Corredor, Timothy E. Vanderleest…·Joseph F. Arboleda‐Velásquez

This study shows that the APOE3Ch variant reduces tau phosphorylation and regulates Wnt/Cadherin signaling in cerebral organoids from Alzheimer's cases, suggesting a protective mechanism against tauopathy.

7 citations

humanexperimental assay

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