Guillermo de Cárcer

This study shows that matrix stiffness influences breast cancer cell dormancy states, with soft matrices inducing transient dormancy and stiff matrices causing prolonged dormancy.

This study shows that CCNY overexpression causes a fatal metabolic syndrome by disrupting glucose homeostasis and inducing a Warburg-like metabolic shift.

The paper identifies WNK1 kinase as a modulator of microtubule drug response under osmotic stress, showing altered drug sensitivity due to changes in microtubule stability.

This paper shows dinaciclib increases radiosensitivity in some cancer cell lines by inhibiting CDK12, reducing BRCA1, and promoting p53-dependent senescence.

The paper identifies TPX2 as a gene that increases breast cancer sensitivity to dasatinib by activating the YAP pathway, and shows TPX2 and YAP are biomarkers for poor prognosis and potential dasatinib therapy.