Author

Lokesh Gakhar

University of IowaORCID 0000-0002-3319-1902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Nicholas SchnickeriD· 2 shared Andrew J. Stanfield· 1 shared Bailey J. Deppe· 1 shared Chou‐Long HuangiD· 1 shared Emeleeta A. PaintsiliD· 1 shared Eva MalacariaiD· 1 shared Francesca Antonella AielloiD· 1 shared G. Marozzi· 1 shared

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2025-2025 · peak 2/yr

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10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Nicholas SchnickerORCID

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2 papers

Recent·Most cited

BiochemistryNaturePeer-reviewedApr 2, 2025

A double-ring of human RAD52 remodels replication forks restricting fork reversal

Masayoshi Honda, Mortezaali Razzaghi, Paras Gaur…·Pietro Pichierri

The paper shows human RAD52 forms a double-ring structure around stalled replication forks, remodeling them via DNA strand exchange to prevent reversal by SMARCAL1.

18 citations

humancryo-EM

𝕏 PostBluesky

BiophysicsScientific ReportsPeer-reviewedJan 2, 2025

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy

Nicholas Schnicker, Zhen Xu, Mohammad Amir…·Chou‐Long Huang

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

5 citations

cryo-EMexperimental assay

𝕏 PostBluesky