Chou‐Long Huang

This study shows that ER-mitochondria disconnection in ADPKD causes metabolic reprogramming and cyst formation, and restoring this connection reduces disease symptoms.

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

This paper develops an extracellular flux analysis to study mitochondrial respiration and energy metabolism in isolated renal tubules, showing transport activity regulates mitochondrial bioenergetics and biogenesis.

The paper shows that chloride levels in Drosophila pacemaker neurons regulate circadian rhythms via a WNK-Fray signaling cascade and potassium channel activity.