Menna Ruth Clatworthy

The paper integrates multiple single-cell and single-nucleus RNA-sequencing datasets to create a comprehensive Human Kidney Cell Atlas, identifying cell types, states, and disease-associated populations.

TERRA is a foundation model for spatial transcriptomics that predicts tissue behavior under perturbation and identifies multi-scale biological insights across tissues.

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

This study investigates the B-cell response to transient HIV viraemia in elite controllers, revealing TLM heterogeneity and the role of innate-like B cells.

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

This study shows that intestinal immunological challenges shape the polarization of dural CD4 T cells, which provide protective memory against pathogens.

MintFlow is a generative AI algorithm that predicts how tissue perturbations reprogram cell states in disease, revealing novel cell populations and therapeutic targets in three human conditions.

The paper identifies increased myeloid-driven inflammation in the CNS of prodromal Parkinson's Disease patients, linking gut and CNS immune responses through shared T cell clones.

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Chronic social defeat stress increases meningeal neutrophils via type I interferon signaling from skull bone marrow, contributing to behavioral issues, and blocking this pathway reduces neutrophil trafficking and improves behavior.

The paper identifies a core transcriptional program driving the human renal mesenchymal-to-epithelial transition using human renal organoids and multi-ome profiling.

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

The paper uses a convolutional neural network to identify regulatory motifs and their cell type-specific importance from single-cell data, explaining 29% of gene expression variance in mouse tissues.

This paper uses spatial transcriptomics and single-cell data to identify cellular niches in the human heart, revealing new insights into cardiac function and potential drug targets.

A multi-regional single-cell study of kidney tumours reveals clonotypic heterogeneity, immune cell exhaustion, and potential therapeutic targets through transcriptomic and exomic analysis.

This study evaluates the impact of cold storage on scRNAseq data quality for lung, spleen, and oesophagus tissues, finding minimal effects within 24 hours but increased stress markers at 72 hours.

The study compares cold storage and normothermic machine perfusion (NMP) on kidney transcriptomes, showing haemoadsorption reduces inflammation and enhances energy metabolism.