Author

James R. Springstead

Western Michigan UniversityORCID 0000-0002-3352-2687Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Ivan ZanoniiD· 2 shared Marco Di GioiaiD· 2 shared Piao Jian Tan· 2 shared Roberto SpreaficoiD· 2 shared Alex G. CuencaiD· 1 shared Anne Chu· 1 shared Ce GaoiD· 1 shared Federica MeloniiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Ivan ZanoniORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 29, 2025

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.

Océane Dufies, Marco Di Gioia, Roberto Spreafico…·Ivan Zanoni

The paper shows that chronic exposure to oxidized phospholipids primes and activates NLRP3 via NRF2, independent of microbial cues, contributing to atherogenesis.

1 citation

mousehuman

𝕏 PostBluesky

ImmunologybioRxivPreprintNov 21, 2023

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

Marco Di Gioia, Valentina Poli, Piao Jian Tan…·Ivan Zanoni

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

5 citations

mousehuman

𝕏 PostBluesky