Ivan Zanoni

The paper shows that chronic exposure to oxidized phospholipids primes and activates NLRP3 via NRF2, independent of microbial cues, contributing to atherogenesis.

This study shows DNASE1L3 clears surface DNA on B and T cells, and variants in DNASE1L3 are linked to higher surface DNA levels in autoimmune disease.

This study investigates how adjuvant conditioning affects peritoneal macrophages and neutrophils, revealing a suppressive macrophage phenotype and enhanced neutrophil function.

This study shows that recipient-derived ILC2s promote allograft survival by inducing anergy in alloreactive CD4+ T cells through antigen presentation and the Caspase-3 pathway.

This study shows that adjuvant conditioning via alum induces immunosuppression through the NLRP3/IL-1 axis, promoting trained tolerance in allografts and human cells.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

The paper develops an engineered bacterium-based RNA interference therapy that reduces inflammation in an IBD model by targeting TNF-alpha.