Iris Bruchhaus

This study compares immune responses to pathogenic and non-pathogenic E. histolytica clones in mice, finding distinct temporal transcriptomic profiles linked to disease severity.

The paper develops a system to study PfEMP1, a key malaria parasite virulence factor, by generating parasites expressing a single PfEMP1 variant and enabling genome edits to investigate its function.

This study identifies JNK as a key integrator of immune and stress signals in airway progenitors, balancing apoptosis and proliferation to maintain tissue homeostasis during inflammation.

A marsh samphire extract extends female Drosophila lifespan and reduces body fat, with effects dependent on Tor signaling and counteracting intestinal barrier loss.

This study shows that JAK/STAT signaling in Drosophila airway epithelia must be balanced to maintain homeostasis and stress adaptation, with both insufficient and excessive activity causing pathology.

This study shows that extracellular vesicles from Entamoeba histolytica drive pro-inflammatory monocyte signaling, contributing to male-biased immunopathology in amebic liver abscesses.

The paper shows that Plasmodium falciparum-infected red blood cells alter gene expression in brain endothelial cells, activating immune and antiviral pathways, and increasing cytokine and angiogenesis-related genes.

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.

The paper identifies PfEMP1 variants associated with severe malaria in first-time infected adults and non-severe cases using RNA-seq and var gene analysis.