Author

Robert H. Silverman

Cleveland ClinicORCID 0000-0003-2432-992XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Abhishek AsthanaiD· 2 shared Anders Henrik LundiD· 1 shared Anthony R. FehriD· 1 shared Chengjin YeiD· 1 shared Christina GaughaniD· 1 shared Clayton J. OtteriD· 1 shared Ebba K. BlomqvistiD· 1 shared Frederic Schrøder ArendrupiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Abhishek AsthanaORCID

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2 papers

Recent·Most cited

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedApr 3, 2024

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

Clayton J. Otter, Nicole R. Bracci, Nicholas A. Parenti…·Susan Reich Weiss

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

59 citationstop 1%

humanbulk RNA-seq

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ImmunologyCell ReportsPeer-reviewedMar 28, 2024

Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L

Jiajia Xi, Goda Snieckute, José Francisco Martínez…·Robert H. Silverman

This study shows that RNase L activation by 2-5A triggers a ZAK-dependent ribotoxic stress response, leading to inflammatory gene transcription and apoptosis.

27 citations

humanbulk RNA-seq

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