Valérie Dutoit

This paper develops an organotypic human tissue platform to assess CAR-T cell toxicity and shows it can predict tissue-specific toxicity profiles and identify factors influencing off-tumor effects.

This study uses cryo-expansion microscopy to visualize the nanoscale architecture of immune synapses in T cells and their interactions with tumor cells, revealing structural details of signaling molecules and lytic granules.

This study develops and validates anti-PTPRZ1 RNA CAR-T cells for glioblastoma treatment, showing antigen-specific and bystander antitumor activity in preclinical models.