Carsten Janke

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

This study shows tau forms multilayered condensates on microtubules via a prewetting-like transition, creating a selective microenvironment that restricts some proteins while recruiting others.

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

This study shows that reduced microtubule polyglutamylation causes neuronal dysfunction and worsens Tau-induced neurodegeneration in mice.

This study shows that loss of tubulin tyrosination in Purkinje neurons does not lead to their degeneration, unlike polyglutamylation dysregulation.

This study identifies MTCL1 as a factor linking microtubule stabilization and acetylation, showing its role in neuronal function through molecular mimicry.

This study shows that tau phosphorylation impairs the protective function of tau envelopes, leading to microtubule destabilization in neurodegenerative disorders.

This study reconstitutes vimentin networks in vitro using cell extracts, showing that cytosolic factors, not filament properties, determine network architecture and mechanics, which vary by cell type.

The paper investigates Eml1 mutations in mice, finding altered organelle distribution and translation defects in radial glia cells, contributing to subcortical heterotopia.

This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.

The paper shows Trim69 remodels microtubules to inhibit HIV virion core migration by stalling dynein/dynactin complexes.

This study shows that Ccp1 depletion in hippocampal parvalbumin interneurons leads to hyperglutamylation, impaired axonal transport, and reduced perisomatic inhibition of pyramidal cells in the CA2 region.

The paper develops a mass spectrometry pipeline to quantify tubulin polyglutamylation in Trypanosoma brucei flagella, identifying novel glutamylation sites and crosstalk with detyrosination.

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

The paper shows that co-polymerization of different tubulin isotypes creates sectioned microtubules that differentially bind MAPs like TPPP1 and OPTN.

The paper uses cell-free assays to show PACRG and FAP20 synergistically stabilize microtubule doublets by reducing B-tubule depolymerization and increasing rescue frequency.

This paper shows FKBP12 inhibits CRMP2A-mediated microtubule polymerization and axon growth by binding to unphosphorylated CRMP2A.

This study shows that glutamylation imbalance in photoreceptor cells leads to structural defects and degeneration, highlighting its role in maintaining outer segment architecture.

The paper shows that choroid plexus cilia undergo axoneme resorption through microtubule destabilization, controlled by polyglutamylation and spastin, and is conserved in human samples.

The paper shows that tubulin polyglutamylation regulates microtubule-severing enzymes in axon guidance, with TTLL6 and TTLL11 having distinct roles in zebrafish and mammalian neurons.

This study shows that ATAT1-enriched vesicles are transported along axons to acetylate -tubulin, essential for proper vesicular transport.