Étienne Meunier

This study uses dual human lung models to evaluate anti-tuberculosis drugs and host-directed therapies, revealing compartment-specific efficacy and immune responses.

This study shows hypervirulent Klebsiella pneumoniae uses its capsule to prevent neutrophil activation, allowing bacterial survival despite immune presence.

The paper identifies PP1 and PP2A phosphatases as regulators of NLRP1 inflammasome activation, showing that environmental toxins and viral infections trigger this pathway via TAK1 and p38 kinases.

This paper identifies two distinct MAP3K pathways activated by beetle toxins that trigger NLRP1 inflammasome activation in human keratinocytes.

This study shows that the hypervirulent Klebsiella pneumoniae capsule masks O-antigen, preventing neutrophil recognition and killing, while O-antigen can also trigger neutrophil degranulation and NET formation.

This study shows GSDMD-mediated ATP release as an early transient danger signal during NLRP3 inflammasome activation, preceding cell death and IL-1β release.

This study identifies Nrf2 as a key factor in Leishmania infantum infection by protecting macrophages from ferroptosis-like cell death, suggesting it as a therapeutic target for visceral leishmaniasis.

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.