Author

Karin Santoni

Imperial College LondonORCID 0000-0002-5688-9844Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Étienne MeunieriD· 2 shared Gad M. FrankeliD· 2 shared Joshua L. C. WongiD· 2 shared Jaie Rattle· 1 shared Renaud PoinclouxiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

Étienne MeunierORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 25, 2026

The capsule of hypervirulent Klebsiella pneumoniae maintains neutrophils in neutral activation state

Karin Santoni, Joshua L. C. Wong, Jaie Rattle…·Gad M. Frankel

This study shows hypervirulent Klebsiella pneumoniae uses its capsule to prevent neutrophil activation, allowing bacterial survival despite immune presence.

DOI 10.64898/2026.02.24.707717

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 26, 2025

Capsule-mediated O-antigen masking protects hypervirulent Klebsiella pneumoniae from neutrophil killing

Karin Santoni, Joshua L. C. Wong, Renaud Poincloux…·Gad M. Frankel

This study shows that the hypervirulent Klebsiella pneumoniae capsule masks O-antigen, preventing neutrophil recognition and killing, while O-antigen can also trigger neutrophil degranulation and NET formation.

1 citation

mouseimaging

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