Michelle Peckham

The paper uses iPALM to determine the 3D organisation of three proteins in cardiac muscle Z-discs, revealing differences in their arrangement.

The paper determines the cryo-EM structure of shutdown human non-muscle myosin 2A, revealing ionic interactions and explaining differences in shutdown mechanism compared to β-cardiac myosin.

This study investigates MEGF10's role in myoblast fusion and muscle hypertrophy, finding that it inhibits fusion and promotes satellite cell adhesion and survival.

This study uses multiscale techniques to reveal the molecular structure of autoinhibited KIF5A, showing how its C-terminal tail contributes to autoinhibition and how mutations affect this state.

This study investigates how alternative splicing, specifically nonsense-associated altered splicing (NAS), affects the pathogenesis of CEP290-related ciliopathies by analyzing splicing patterns and ciliogenesis in induced pluripotent stem cells.