Jacob J. Zulk

This study identifies immune signatures in mice and human urine that predict preterm birth risk following UTI, highlighting cytokines like IL-10 and IL-15 as potential therapeutic targets.

This study shows that type 2 diabetes increases susceptibility to vaginal group B Streptococcus colonization through impaired cytokine responses, not via glucose availability or microbiome changes.

This study shows that bacteriophages can reduce uropathogenic E. coli (UPEC) colonization in vitro and in a mouse model, suggesting phage therapy as a potential UTI prevention strategy.

This study develops human bladder organoids to model UTIs and phage therapy, showing phage reduces bacterial loads and inflammation during infection.

This study shows that Tamm-Horsfall protein enhances neutrophil NETosis during UTI by modulating respiratory chain, granules, and chromatin remodeling pathways.