Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against MCM reloading and tetraploidy
Yoko Hayashi‐Takanaka, Ichiro Hiratani, Tokuko Haraguchi, Yasushi Hiraoka
The paper shows that proteasome-dependent removal of Orc6 from chromatin during S-phase prevents abnormal MCM reloading and tetraploidy in human cells.