Ulf P. Neumann

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

The paper identifies microbial bile salt conjugates that activate TGR5 and FXR receptors in human systems and quantifies their presence in blood and bile.

This paper presents an optimized workflow for isolating and analyzing extracellular vesicles from plasma and serum in liver diseases, identifying miRNAs and cytokines as potential biomarkers.

The paper develops a physiology-based model of bile acid metabolism to predict drug-induced liver injury risk and genetic susceptibility.