Tom Luedde

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

This study investigates whether ACSL4 deletion in liver cells prevents MASLD progression in mice but finds no significant differences compared to wild-type mice.

This study shows that Salmonella SopB suppresses mucosal inflammation and disease progression in a phosphatase-independent manner during infection.

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

This study identifies miR-122 as a key regulator in inflammation-associated liver cancer, showing its differential modulation by TGFbeta1 and BMP6 and its link to chronic liver disease.

This paper presents an optimized workflow for isolating and analyzing extracellular vesicles from plasma and serum in liver diseases, identifying miRNAs and cytokines as potential biomarkers.

This paper demonstrates swarm learning for training AI models on decentralized histopathology data to predict molecular features in colorectal cancer.

This paper develops a deep learning method to predict genetic alterations from histological images across multiple cancer types.