Carlos F Fernandez-Hernando

This study shows that loss of NgBR/cis-PTase function in the liver leads to fatty liver disease that progresses to hepatocellular carcinoma with 100% penetrance, and DGAT2 inhibition prevents this progression.

This study shows LPHN2 is essential for flow-induced Notch activation to suppress inflammation and atherosclerosis in endothelial cells.

This study shows that endothelial ANGPTL4 depletion prevents diabetic kidney disease by improving metabolic function and reducing inflammation.

This study identifies Angptl4 as a fibrogenic molecule in diabetic kidney disease and shows that targeting its expression in kidneys reduces fibrosis and proteinuria.

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.