Jianming Hu

The paper determines the structures of mature HBV and Duck HBV, revealing that DNA forms a spool within the capsid that interacts with interior charges and creates a metastable state for genome uncoating.

This study shows that replication-driven cccDNA loss occurs in HBV-infected chimeric mice with humanized livers, and blocking cccDNA replenishment pathways significantly reduces cccDNA levels.

This paper develops a whole-cell computational model of HBV infection and drug interactions to predict infection pathways and optimal drug dosing.