Jeffrey Wade Brown

This study shows that galectin-8 modulates CD44v membrane localization and suppresses STAT3 signaling in gastric metaplasia, with implications for cancer prognosis.

This study shows galectin-3 promotes cathartocytosis in gastric chief cells, facilitating metaplasia development by enabling sulfomucin vesicle secretion.

This study identifies IFRD1 as a ribosome-salvaging factor that stabilizes non-translating 80S ribosomes during ER stress, preventing degradation and cell death.

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

The paper investigates the role of multimerin-1 in gastric chief cell differentiation by tempering WNT signaling, revealing its importance in epithelial maturation through interactions with mesodermal cells.

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

This study identifies IFRD1 as a key regulator of ER stress and urothelial homeostasis in mice, showing its role in maintaining bladder function and preventing cell shedding.

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.