Helmut Blum

This study identifies the IFN-STAT1/STAT5B-SOCS1 axis as a mechanism by which respiratory viruses activate autophagy, showing that targeting this pathway can inhibit virus replication without compromising innate immunity.

The paper uses microscopy to study delayed co-transcriptional splicing in the highly expressed thyroglobulin gene, finding a delay in splicing downstream of transcribed introns.

This study identifies ARID1A mutations in follicular lymphoma that reduce FAS expression, enabling immune evasion by disrupting RUNX3/ETS1 regulation.

This study uses HIV-guided CRISPR to identify antiviral factors by analyzing sgRNA enrichment during viral replication.

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

The paper identifies HOXB13 as a candidate gene for tail length variation in Merinolandschaf sheep through haplotype mapping and candidate variant analysis.

This study shows OCT4 is essential for maintaining pluripotency in the epiblast and differentiation of the hypoblast in bovine embryos.

This paper introduces Swarm Learning, a decentralized machine learning approach for disease classification using transcriptomic data, demonstrating its effectiveness in developing classifiers for COVID-19, tuberculosis, and leukemias while preserving privacy.

The paper introduces a method to measure nucleosome array regularity and spacing using nanopore sequencing, revealing relationships with chromatin states and promoter activity.

This paper uses taxogenomics to identify a new genus and species in Placozoa based on genome comparisons.

A 125-megabase draft genome of the contractile demosponge Tethya wilhelma reveals extensive lineage-specific expansions, losses, and domain rearrangements across early metazoan neural signaling gene families.