Tyler Weaver

The paper presents cryo-EM structures of a Blm10:13S proteasome intermediate, revealing parallel assembly pathways for the proteasome core particle involving Blm10 and Pba1/Pba2.

This study investigates how DNA Ligase IIIα ligates nicks in nucleosomes using biochemical assays, molecular dynamics, and cryo-EM, revealing position-dependent efficiency and structural constraints.

This study defines the structural basis of how PNKP processes non-ligatable SSBs in the nucleosome using cryo-EM and biochemical assays.

This study reveals how APE1 uses a dynamic search mechanism combining 1D and 3D diffusion to efficiently locate and repair AP-sites in DNA.

This study investigates how PARP1 binds to DNA breaks and chromatin, revealing that nucleosome unwrapping and allostery influence its affinity and binding dynamics.

This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.

This study determines the structural and kinetic mechanism of DNA Polymerase β processing 1-nt gaps in the nucleosome during DNA repair.

This study identifies factors influencing 8-oxoG-induced mutagenesis in human cells, revealing a hierarchical DNA repair network and chromatin structure effects on mutation patterns.

This study compares single-molecule DNA binding dynamics of purified OGG1 and nuclear extracts using SMADNE, revealing differences in undamaged DNA binding and increased binding lifetime for a catalytically dead variant in nuclear extracts.

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.