Christopher G. Bunick

This paper determines the crystal structure of rademikibart Fab-IL-4Rα complex and performs MD simulations to show its superior binding and inhibition of IL-4R compared to dupilumab.

This study reveals how tetracyclines target the bacterial ribosome using cryo-EM structures, showing species-specific interactions and a new mechanism for antibiotic action.

This paper describes the structural basis of STAR-0310, a novel anti-OX40 antibody, which prevents OX40 signaling through a dual mechanism of blocking receptor trimerization and disrupting pre-formed complexes, showing greater efficiency than comparator antibodies.

This paper investigates the triple-action inhibitory mechanism of deucravacitinib on TYK2, revealing its inhibition in three distinct states and structural basis for selectivity.

This paper analyzes the structural epitopes of IL-23 inhibitors and finds that epitope surface area correlates with clinical efficacy in psoriasis treatment.