Matthias W. Hentze

This study shows PKM2 binds RNA through a positively charged surface patch, with RNA binding influenced by its oligomeric state and allosteric regulator FBP.

This paper introduces soniCLIP, a CLIP-seq method that improves RNA target identification for RBPs by reducing input requirements and workflow complexity.

This study shows that liver sinusoidal endothelial cells (LSECs) integrate metabolic and immune signals through the MAPK pathway to regulate BMP6 and induce hepcidin, maintaining iron homeostasis during inflammation and stress.

This study identifies MLP as a non-canonical RNA-binding protein in cardiomyocytes and shows its RNA-dependent interaction with cytoskeletal complexes.

The paper shows that genomic G quadruplexes regulate mRNA splicing by recruiting RNA-binding proteins, with implications for cardiac function.

The paper shows that specific cytosolic RNAs bind ATP5A1 precursor proteins and promote their mitochondrial import.

This study identifies RNA-binding activity of mitochondrial MDH2, showing it preferentially binds cytosolic RNAs and its RNA-binding is influenced by NAD+ levels.

DEWSeq improves eCLIP data analysis by increasing the detection of RNA-binding protein binding sites and their functional elements.

The paper characterizes RNA-binding protein landscapes in mouse organs using ex vivo eRIC, identifying over 1300 RBPs, many not previously found in cultured cells.

The paper introduces snRIC2C, a method to identify small non-coding RNA-binding proteins, revealing that glycolytic enzymes like GAPDH bind tRNAs in a carbon source-dependent manner.

The paper shows RNA regulates ENO1 enzyme activity, affecting glycolysis and stem cell differentiation in human and mouse cells.

The paper identifies the molecular mechanism by which vault RNA1-1 regulates p62 oligomerisation, essential for selective autophagy.

This study identifies vault RNA1-1 as a riboregulator of autophagy by interacting with p62, showing that it modulates autophagic flux.

The paper introduces XRNAX, a method to purify protein-RNA complexes, and shows it captures all RNA biotypes and reveals dynamic changes in the RNA-bound proteome during arsenite-induced stress.