Manuel J. Gómez

This study shows that activating HIF2 causes vascular remodeling, inflammation, and coronary issues similar to Kawasaki disease, using a new mouse model and human tissue analysis.

This study shows that gut Enterococcus faecalis induces trained immunity in myeloid bone marrow progenitors via the C-type lectin receptor Mincle, contributing to inflammation linked to gut permeability.

This study identifies ATF4 as a critical regulator of OXPHOS assembly and function by analyzing human and murine cell lines with OXPHOS defects.

This study identifies Nrg1-ErbB2/4-pErk signaling as critical for cardiomyocyte cell cycle progression, migration, and trabeculation during ventricular development, with implications for cardiac regeneration.

The paper investigates the effects of HIF1 deletion in cardiac progenitors, finding that it leads to impaired glycolysis and activation of an amino acid metabolic program without affecting heart development or function.

This study identifies a Dll4-Jag1-EphrinB2 signaling cascade that regulates coronary arterial development in mice.

This study identifies Nanog as a repressor of Pou3f1, which inhibits anterior neural fate during gastrulation in mouse embryos.

This study investigates the effects of HIF1α deletion in cardiac progenitors during heart development, finding that HIF1 is dispensable for cardiac growth and reveals metabolic reprogramming toward amino acid utilization.