Damage sensing recruitment of a lipid phosphatase couples lysosomal membrane repair to proteostatic adaptation
Yanwei Su, João Mello-Vieira, Dmytro Puchkov…·Volker Haucke
This study shows MTMR14 is recruited to damaged lysosomes to remodel lipids, reduce mTORC1 signaling, and support proteostasis during lysosomal injury.