Volker Haucke

This study identifies structural elements and dynamics of the Mic60-Mic19 subcomplex crucial for MICOS assembly and crista junction formation.

The paper maps the spatial and structural proteome architecture of HEK293 cells using subcellular fractionation and cross-linking mass spectrometry, identifying residue-level protein interactions and expanding the human cell interactome.

The paper investigates the role of hypothalamic NPY/AgRP neurons in regulating age-related presynaptic remodeling through autophagy and non-cell autonomous mechanisms.

This study shows MTMR14 is recruited to damaged lysosomes to remodel lipids, reduce mTORC1 signaling, and support proteostasis during lysosomal injury.

The paper identifies that lysosomal cholesterol exchange regulates motility through mTOR-dependent LAMTOR1 phosphorylation, revealing a feedback mechanism affecting mTORC1 activity and lysosomal movement.

This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.

This study shows that mTORC1-dependent translation in layer 5b neurons is essential for memory consolidation through activity-dependent plasticity.

This study shows that AP2 complex is essential for myelin sheath biogenesis and homeostasis, with loss of AP2 causing hypomyelination and hypermyelination in different developmental stages.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

This paper develops a fluorescent probe to detect malaria-infected red blood cells and demonstrates its use with a smartphone microscope for diagnostic applications.

The paper identifies two functionally distinct ARF1 compartments involved in post-Golgi sorting and endocytic recycling, challenging the classical vesicle shuttling model.

The paper introduces OrgaMapper, a workflow for analyzing organelle positioning, demonstrating its robustness against common challenges in assessing positioning phenotypes.

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.

This study identifies mDia1/3 and Rho GTPase signaling as critical regulators of presynaptic actin dynamics and endocytosis.

This study develops NMDA-receptor-Fc-fusion constructs that neutralize anti-NMDA receptor antibodies and inhibit their effects on neurons.

The paper shows that SV endocytosis in hippocampal neurons occurs clathrin-independent, but AP-2 mediates retrieval of specific SV proteins.

This study shows that neuronal autophagy regulates axonal ER calcium stores to control neurotransmission and postnatal viability in mice.

The paper identifies protein-protein interactions on Chr21 linked to intellectual disabilities, autism, and Alzheimer's by analyzing yeast two-hybrid screens and synaptic localization.

The paper identifies homozygous mutations in PIK3C2A causing a new Mendelian disorder with short stature, skeletal abnormalities, cataracts, and ciliary dysfunction.