Andres M. Lebensohn

This study shows that fatty acid metabolism regulates plasma membrane cholesterol accessibility through ATGL-dependent phospholipid remodeling, affecting membrane fluidity and cholesterol signaling.

This study identifies HUWE1 as a regulator of WNT signaling through two mechanisms: antagonizing destruction complex-mediated β-catenin degradation and an independent pathway, both requiring HUWE1's ubiquitin ligase activity.

This study identifies NFAT5 as a direct sensor and effector of ionic stress in animal cells, showing it forms condensates to activate genes restoring ion balance.

The paper identifies cis-regulatory elements by analyzing gene trap insertions in haploid human cells using WNT signaling screens.

This study shows RSPO2 and RSPO3 can enhance WNT/β-catenin signaling without LGR receptors, while RSPO1 and RSPO4 cannot, revealing two distinct RSPO signaling mechanisms.