Indrani Nayak

The paper uses nonlinear mixed-effects modeling to study synergy between immune checkpoint and thrombin inhibitors in a mouse colon cancer model, identifying mechanisms like CD8+ T cell expansion.

The paper develops a multiscale computational model to predict CD33 CAR-NK cytotoxicity against various target cells using experimental data and flow cytometry.

This study shows that SYK negatively regulates NK cell signaling and that its deletion enhances CD19-CAR NK cell efficacy in cancer immunotherapy.

This study shows that NK cell receptor signaling and activation vary with cell cycle stages, with some proteins showing non-monotonic abundance changes.

The paper assesses the impact of IL-21 on NK cell proliferation and function using mathematical and functional approaches, finding synergy between STAT3 and NF-κB and optimal IL-21 use in the priming phase.