Kristen E. Pauken

This study identifies distinct transcriptional features in fibroblasts and myeloid cells of ICI-LP compared to LP, highlighting differences in IGF1, JAK-STAT, and interferon pathways.

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

This study shows that dietary methionine restriction enhances T cell metabolism and improves anti-PD1 checkpoint blockade efficacy in immunocompetent tumor models.

This study shows that changing antibody administration route and fluorophore improves leukocyte labeling efficiency, sensitivity, and duration for tracking migration.

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.