Sara Lopes

This study investigates the role of aging in Machado-Joseph disease by analyzing age-related markers in human and animal models, finding decreased lamins and ZMPSTE24 levels and nuclear abnormalities.

This study evaluates the therapeutic potential of mesenchymal stromal cells (MSC) in mitigating vascular abnormalities and blood-brain barrier (BBB) disruption in Machado-Joseph disease (MJD) transgenic mice, showing partial restoration of vascular and BBB integrity.

This paper develops and tests rAAV-delivered bicistronic artificial microRNAs to selectively silence mutant ATXN3 in SCA3 mouse models, showing improved motor function and reduced mutant protein aggregates.

This study investigates circadian rhythm disruptions in Machado-Joseph disease patients and preclinical models, finding impaired clock gene expression and disrupted activity and temperature rhythms.

This study characterizes the genetic and antigenic diversity of H1 and H3 influenza A viruses in Brazilian swine from 2010-2018, identifying distinct lineages and antigenic variation with implications for vaccine development.