Amy L. Vincent Baker

This study evaluates an H5 mRNA-LNP vaccine in lactating dairy cows, finding it reduces viral replication and disease in mammary glands.

This paper develops a multivalent mRNA-LNP vaccine with eight swine IAV HA antigens, showing broad neutralizing antibodies and protection against viral challenge.

This study evaluates the immune response of an H5 mRNA-LNP vaccine in calves against H5N1 influenza, showing robust antibody and CD8+ T cell responses and protection against infection.

This study examines how maternal antibodies and weaning stress affect piglets' susceptibility to human H3N2 influenza A virus, showing that matched maternal antibodies reduce shedding and transmission while weaning increases viral spread.

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

This study uses lectin histochemistry to examine sialic acid receptor distribution in mammary glands of livestock and humans, finding SA 2,6-Gal and SA 2,3-Gal receptors that enable IAV binding.

This study quantifies the sources and sinks of influenza A virus genomic diversity in U.S. swine from 2009 to 2022, showing regional hotspots and the role of swine transport in diversity spread.

The paper conducts active surveillance of influenza A virus in swine farms and nurseries, revealing within-farm reassortment, cocirculation of subtypes, and human-to-swine transmission events.

TreeSort detects influenza A reassortment in thousands of genomes via clock-based tests; avian H7 reassorts most, and HA, NA, MP rarely reassort in human and H5N1.

This study identifies a reassortment event in wild birds leading to HPAI A(H5N1) infection in cattle and highlights the risk of virus spread through asymptomatic cattle to humans.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

The paper shows human seasonal H3N2 influenza A viruses can transmit to pigs but are not sustained in the pig population, with limited spread and transmission observed.

This study experimentally reproduces HPAI H5N1 infection in dairy calves and cows, confirming clinical disease and viral transmission through respiratory and mammary routes.

The paper assesses the pandemic risk of swine H1N2 influenza viruses by analyzing their transmission potential and immune response in ferrets.

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.

This study characterizes the genetic and antigenic diversity of H1 and H3 influenza A viruses in Brazilian swine from 2010-2018, identifying distinct lineages and antigenic variation with implications for vaccine development.